Software

CLOCI aids genome-guided drug discovery by accurately detecting colocalized, coordinately functioning genes, or gene clusters, that underly the synthesis of microbial natural products. CLOCI enables efficient detection to heterologous expression of pathways of interest, benchmarking at 0 median extraneous and missing genes per reference cluster. CLOCI recovers reference biosynthetic gene clusters with a 15% improvement compared to the leading standard, antiSMASH. The CLOCI approach is suited for identifying drug lead-producing gene clusters that were previously overlooked, such as the neuroactive psilocybin synthesis cluster. Checkout the manuscript.

Mycotools is a foundation for automating genomics research. Mycotools software suite includes modules for automating routine-complex comparative genomics. Mycotools was originally constructed for fungi, though its taxonomy-agnostic framework is now suitable for plants and prokaryotes. Check out the usage guide. and preprint for more information.